Cancer Therapy: Prognostic Factors and Criteria of Response

Abstract

673 of radiobiology and cell survival and their application to therapy. The hardback edition increases the price unnecessarily, especially as it could well have been published in a Review series. Apart from the serious omission of pages 339-340 and 365-366 from two of the four copies I have seen, the book (with complete pagination) is recommended as an up-to-date review of the state of this art. Cancer chemotherapy is now expanding rapidly due to the elaboration of combination schedules and the introduction of new drugs. It is of prime importance therefore, that clinical trials are conducted correctly to assess the response to therapy. This book brings together the expertise and knowledge of prominent workers in the field of cancer therapy who, between them, have produced a valuable text for any clinician involved in assessing cytotoxic drugs. The book is well written and contains ample figures and tables. There are 21 chapters. The first 3 are devoted to methodology and I found the section on statistical methods for survival studies particularly interesting. The following 6 chapters are devoted to the lympho-reticular disorders, all well covered, with the possible exception of the chapter devoted to non-Hodgkin's lymphoma. The remaining chapters are devoted to solid tumours. Each chapter details criteria for response and appropriate parameters for assessment, followed by a comprehensive bibliography. The book is strongly recommended to cancer chemotherapists, and also to radiotherapists. It is probably too specialized 44* for other specialities but should find a place in the appropriate library. This volume is the first of a series on "Advances in Tumour Prevention, Detection and Characterisation ", edited by C. Maltoni, in which it is intended to include critical reviews, experimental studies and symposia. It contains the proceedings of the 5th International Symposium held at Bologna, Italy in 1973 on the characterization of human tumours. The programme was varied and it struck a good balance between clinical and experimental research. The reports are divided into chapters covering biological aspects of carcinogenesis, the role of viruses in human cancer, chemical carcinogenesis, mammary tumours (a particularly interesting chapter), immunology and experimental and clinical studies. Each chapter contains at least one review lecture given by an expert in his chosen field; these are well written and we are given a fascinating series of viewpoints ranging from a consideration of molecular interactions at the cell surface to epidemiological aspects of mammary tumours. These papers could …

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